Glibenclamide is known as one of the efficacious medicines for diabetes.

The medicine is manufactured with such expensive chemical reagents as chloroform and potassium carbonate.

After years of research, the institute developed a method of manufacturing the medicine without using the reagents.

The new method sharply shortens the manufacturing time, while raising the actual extraction rate by 50 percent.

Phosgene is never used in making antidiabetic in the DPRK.